{"product_id":"foxo4-dri-15mg","title":"FOXO4-DRI: Advanced Senolytic Peptide for Healthy Aging, Cellular Rejuvenation, Tissue Regeneration, Long-Term Vitality","description":"\u003cstyle\u003e\n.grid1 { display: grid; grid-template-columns: auto 42%; grid-column-gap: 95px; }\n.grid-content { margin-top: 10px; }\n.grid2 { display: grid; grid-template-columns: 42% auto; grid-column-gap: 95px; }\n.grid3 { display: grid; grid-template-columns: auto 42%; grid-column-gap: 95px; margin-top: 40px; }\n.benefits-img { margin-top: 10px; }\n.grid4 { display: grid; grid-template-columns: 42% auto; grid-column-gap: 120px; margin-top: 40px; }\n.grid5 { margin-top: 50px; }\n.grid6 { margin-top: 50px; }\n.packaging-content { margin-top: 40px; }\n\n\/* FAQ Section - Full Width *\/\n.faq-full {\n    width: 100%;\n    padding: 20px 0;\n}\n\n.faq-full h3 {\n    font-size: 2rem;\n    font-weight: 700;\n    margin-bottom: 25px;\n    color: #2d2f36;\n    text-align: center;\n}\n\n.faq-full p {\n    margin-bottom: 1.2rem;\n    line-height: 1.6;\n    color: #1a1e2b;\n}\n\n.faq-full p strong {\n    font-weight: 700;\n    color: #2c2f36;\n    display: block;\n    margin-bottom: 2px;\n}\n\n\/* Responsive *\/\n@media screen and (max-width: 780px) {\n    .grid1 { display: block; }\n    .grid2 { display: flex; flex-direction: column-reverse; }\n    .grid3 { display: block; }\n    .grid4 { display: flex; flex-direction: column-reverse; }\n    .grid5 { display: block; }\n    .grid6 { display: block; }\n    .benefits-img img { margin-top: 20px; }\n    .stacking-video { margin-top: 20px; margin-bottom: 20px; }\n    .packaging-img img { margin-top: 20px; }\n    .last-img img { margin-top: 20px; }\n    .who-img img { margin-top: 20px; }\n    img { width: 100%; height: auto; }\n    .faq-full { padding: 10px 0; }\n    .faq-full h3 { font-size: 1.6rem; }\n}\n\u003c\/style\u003e\n\n\u003c!-- ========== GRID 1: Product Description + Image 1 ========== --\u003e\n\u003cdiv class=\"grid1\"\u003e\n\u003cdiv class=\"grid-content\"\u003e\n\u003ch3\u003eFOXO4-DRI\u003c\/h3\u003e\n\u003cp\u003e\u003cb\u003eContent:\u003c\/b\u003e\u003cbr\u003e15mg\/vial x 1\u003c\/p\u003e\n\n\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003e\u003cb\u003eFOXO4-DRI\u003c\/b\u003e (also known as Proxofim) is a 46-amino-acid synthetic peptide engineered using the D-retro-inverso (DRI) strategy, designed to selectively eliminate senescent cells—dysfunctional \"aged\" cells that accumulate over time and contribute to chronic inflammation, impaired tissue regeneration, and age-related decline. Developed by Peter de Keizer and colleagues at Erasmus University Medical Center, the peptide was first described in a landmark 2017 publication in the journal Cell.\u003c\/p\u003e\n\u003cp\u003eFOXO4-DRI targets a specific protein-protein interaction between the FOXO4 transcription factor and the tumor suppressor p53, which is uniquely upregulated in senescent cells. By competitively disrupting this interaction, FOXO4-DRI releases p53 from nuclear sequestration, allowing it to translocate to mitochondria and trigger intrinsic apoptosis exclusively in senescent cells, while leaving healthy cells unaffected. This selectivity distinguishes FOXO4-DRI from broader senolytic agents like navitoclax, which can cause off-target effects including thrombocytopenia. The D-amino acid construction provides marked resistance to proteolytic degradation, extending its activity in the body.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"grid-img\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0070\/7441\/4665\/files\/Foxo4-DRI.png?v=1787045410\" alt=\"FOXO4-DRI Front\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003c!-- ========== GRID 2: Benefits + Image 2 ========== --\u003e\n\u003cdiv class=\"grid2\"\u003e\n\u003cdiv class=\"video-container\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0070\/7441\/4665\/files\/FOXO4-DRI_c9359606-e28c-405c-9d81-b186f61342f8.png?v=1787045444\" alt=\"FOXO4-DRI Benefits\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"content-container\"\u003e\n\u003ch3\u003eBenefits\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSelective Senescent Cell Clearance\u003c\/strong\u003e\u003cbr\u003eTargets and eliminates dysfunctional aged cells while preserving healthy cells.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupports Healthy Aging\u003c\/strong\u003e\u003cbr\u003eReduces the burden of senescence-associated secretory phenotype (SASP) factors.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImproves Vascular Function\u003c\/strong\u003e\u003cbr\u003eEnhances endothelial function and vascular elasticity by reducing aging markers in the aorta.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupports Tissue Regeneration\u003c\/strong\u003e\u003cbr\u003ePromotes healthier tissue remodeling and cellular communication.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnhances Cognitive Wellness\u003c\/strong\u003e\u003cbr\u003eMay help restore cerebral blood flow and blood-brain barrier integrity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupports Muscle Recovery\u003c\/strong\u003e\u003cbr\u003eHelps maintain physical resilience and recovery capacity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReduces Chronic Inflammation\u003c\/strong\u003e\u003cbr\u003eLowers inflammatory burden associated with senescent cell accumulation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePromotes Long-Term Vitality\u003c\/strong\u003e\u003cbr\u003eSupports overall physiological function associated with healthy aging.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003c!-- ========== GRID 3: Usage \u0026 Dosage + Cycle Support + Stacking + Image 3 ========== --\u003e\n\u003cdiv class=\"grid3\"\u003e\n\u003cdiv class=\"benefits-content\"\u003e\n\u003ch3\u003eUsage \u0026amp; Dosage Guidelines\u003c\/h3\u003e\n\u003cp\u003eDosage should always be individualized according to treatment goals under professional supervision. Typical research protocols utilize an intermittent \"hit-and-run\" schedule with \u003cstrong\u003e3–6 doses per cycle\u003c\/strong\u003e, repeated 1–3 times per year.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store lyophilized vials at 2–8°C; after reconstitution, refrigerate immediately and avoid freezing.\u003c\/p\u003e\n\n\u003ch3\u003eCycle Support\u003c\/h3\u003e\n\u003cp\u003eRegular medical monitoring is recommended during extended longevity protocols. Maintain proper hydration and a nutrient-dense diet to support cellular health. Given the potent mechanism of action, professional supervision is essential to monitor response and adjust protocols as needed.\u003c\/p\u003e\n\n\u003ch3\u003eStacking\u003c\/h3\u003e\n\u003cp\u003eFOXO4-DRI is commonly incorporated into comprehensive longevity and regenerative wellness protocols alongside mitochondrial-support peptides like MOTS-C, NAD+ therapies, regenerative peptides like BPC-157 and TB-500, or metabolic optimization compounds. Combination protocols should always be individualized according to treatment objectives and health status under professional supervision.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"benefits-img\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0070\/7441\/4665\/files\/FOXO4-DRI_fea785ee-5cae-4936-9e5a-6e517ba3cf37.png?v=1787045469\" alt=\"FOXO4-DRI Usage\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003c!-- ========== GRID 4: Contraindications + Special Precautions + Adverse Drug Reactions + Drug Interactions + Image 4 ========== --\u003e\n\u003cdiv class=\"grid4\"\u003e\n\u003cdiv class=\"who-img\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0070\/7441\/4665\/files\/Foxo4-DRI_897e0434-6774-4a3c-a42a-43c25bb14c70.png?v=1787045481\" alt=\"FOXO4-DRI Precautions\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"who-content\"\u003e\n\u003ch3\u003eContraindications\u003c\/h3\u003e\n\u003cp\u003eDo not use FOXO4-DRI if you are immunocompromised, have an active infection, are pregnant or breastfeeding, or are a child or adolescent. It is also contraindicated in individuals with active malignancy without professional oncology supervision.\u003c\/p\u003e\n\n\u003ch3\u003eSpecial Precautions\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eCritical Safety Warning:\u003c\/strong\u003e FOXO4-DRI is an experimental research peptide with \u003cstrong\u003eno completed human clinical trials and no human safety data available as of 2026\u003c\/strong\u003e. Use should be limited to professionally supervised research settings only. Individuals with autoimmune disorders, chronic medical conditions, or undergoing immunosuppressive therapy should consult their physician before use.\u003c\/p\u003e\n\n\u003ch3\u003eAdverse Drug Reactions\u003c\/h3\u003e\n\u003cp\u003eAvailable adverse effect data is derived primarily from a single preclinical study in mice, including transient gastrointestinal disturbance and injection site reactions. \u003cstrong\u003eHuman safety profile has not been characterized.\u003c\/strong\u003e If severe or persistent effects occur, discontinue use and consult a healthcare professional.\u003c\/p\u003e\n\n\u003ch3\u003eDrug Interactions\u003c\/h3\u003e\n\u003cp\u003eCaution is advised when used with chemotherapy agents, immunosuppressant medications, or other senolytic agents such as dasatinib, quercetin, navitoclax, or fisetin, as additive or synergistic effects could cause excessive tissue damage. No formal drug interaction studies have been conducted.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003c!-- ========== GRID 5: FAQs (FULL WIDTH) ========== --\u003e\n\u003cdiv class=\"grid5\"\u003e\n\u003cdiv class=\"faq-full\"\u003e\n\u003ch3\u003eFrequently Asked Questions (FAQs)\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003e1. What is FOXO4-DRI used for?\u003c\/strong\u003e\u003cbr\u003eFOXO4-DRI is an experimental senolytic peptide designed to selectively eliminate senescent (aged\/dysfunctional) cells to support healthy aging, tissue regeneration, and overall vitality.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e2. How does FOXO4-DRI work?\u003c\/strong\u003e\u003cbr\u003eIt disrupts the FOXO4-p53 interaction specifically in senescent cells, releasing p53 to trigger apoptosis (programmed cell death) while leaving healthy cells unaffected.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e3. Is FOXO4-DRI FDA-approved?\u003c\/strong\u003e\u003cbr\u003eNo. FOXO4-DRI is not FDA- or EMA-approved for any indication and remains in the preclinical research stage with no completed human clinical trials.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e4. Are there human safety data available?\u003c\/strong\u003e\u003cbr\u003eNo human safety data exists. The available information is derived from preclinical mouse studies only.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e5. What is the recommended dosage?\u003c\/strong\u003e\u003cbr\u003eNo established human dose exists. Research community protocols range from 3–25 mg per injection on an intermittent schedule. Dosage should only be determined by a qualified healthcare professional.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e6. What are the common side effects?\u003c\/strong\u003e\u003cbr\u003eReported effects in mouse studies include mild diarrhea and injection site reactions. Human side effects are unknown.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e7. Who should not use FOXO4-DRI?\u003c\/strong\u003e\u003cbr\u003eDo not use if you are immunocompromised, have an active infection, are pregnant or breastfeeding, or are a child or adolescent.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e8. Can FOXO4-DRI be stacked with other products?\u003c\/strong\u003e\u003cbr\u003eTheoretically, it may be combined with mitochondrial-support peptides, NAD+ therapies, or regenerative peptides, but combination protocols should only be determined by a qualified professional.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e9. Is FOXO4-DRI safe for long-term use?\u003c\/strong\u003e\u003cbr\u003eLong-term safety is completely unknown. No formal toxicology studies meeting regulatory standards exist.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e10. Do I need post-cycle therapy (PCT) after using FOXO4-DRI?\u003c\/strong\u003e\u003cbr\u003eFOXO4-DRI does not suppress natural hormones, so PCT is not required. Professional medical supervision is still essential.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003c!-- ========== GRID 6: Disclaimer \u0026 Footer ========== --\u003e\n\u003cdiv class=\"grid6\"\u003e\n\u003cdiv class=\"disclaimer-content\"\u003e\n\u003ch3\u003eDisclaimer\u003c\/h3\u003e\n\u003cp\u003eThe information provided is for educational purposes only and is not intended as medical advice. FOXO4-DRI is an experimental research compound with no established human safety data and should only be used under the supervision of a qualified healthcare professional in an approved research setting. This product is not intended to diagnose, treat, cure, or prevent any disease. Product images are for illustration purposes only and may differ from the actual product. Packaging and labeling are subject to change without prior notice.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003cp style=\"text-align: center; font-size: 0.85rem; color: #5a6874; margin-top: 2rem;\"\u003e🛡️ FOXO4-DRI — Advanced Senolytic Peptide for Healthy Aging, Cellular Rejuvenation, Tissue Regeneration \u0026amp; Long-Term Vitality\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Modified Genetic","offers":[{"title":"Default Title","offer_id":51760861086002,"sku":null,"price":10500.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0810\/2359\/8898\/files\/Foxo4-DRI_f6d96de4-8def-488f-b6c5-6ac1569e13f8.png?v=1789035518","url":"https:\/\/anabolicskart.com\/products\/foxo4-dri-15mg","provider":"Anabolics Kart","version":"1.0","type":"link"}